Table 1 In- and exclusion criteria

• Relapsing remitting or secondary progressive MS

• Pregnant or breast feeding women

• EDSS: 3.0 – 6.0

• Women planning to become pregnant during study period

• Age > 21 years

• Concomitant diseases (internistic, neurological or orthopaedic) limiting the execution of the intervention and assessments or affecting study endpoints

• Informed consent as documented by signature

• Drug or alcohol abuse

• Problems of understanding (not German-speaking), psychological disorders, dementia etc. affecting the ability to understand study course and execute study instructions

• Persons who already participated in the current study

• Enrolment of persons employed for study execution, family members of the investigator and himself

• Acute melanoma and cancer diseases under treatment of chemotherapy or radiation therapy