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Table 2 Clinical, demographic, and patient self-reported associations with the (natural log-transformed) Neutrophil-Lymphocyte Ratio

From: The neutrophil-to-lymphocyte and monocyte-to-lymphocyte ratios are independently associated with neurological disability and brain atrophy in multiple sclerosis

 

Univariable

Multivariable

β

95% CI

p

β

95% CI

p

Age (yrs)

0.023

− 0.011, 0.056

0.188

0.021

− 0.010, 0.053

0.189

Disease Duration (yrs)

0.009

−0.023, 0.040

0.591

−0.013

− 0.048, 0.022

0.477

Gender

 • Female

–

–

–

–

–

–

 • Male

−0.003

−0.083, 0.077

0.942

−0.012

−0.086, 0.062

0.750

Smoking History

 • No

–

–

–

–

–

–

 • Yes

0.001

−0.076, 0.078

0.979

0.018

− 0.054, 0.090

0.621

BMI

−0.008

− 0.045, 0.029

0.666

0.002

−0.033, 0.037

0.910

DMT

 • Untreated

–

–

–

–

–

–

 • Interferon-β

−0.166

− 0.236, − 0.096

< 0.001

− 0.163

−0.233, − 0.093

< 0.001

 • Cyclophosphamide

0.268

0.147, 0.389

< 0.001

0.274

0.152, 0.395

< 0.001

 • Fingolimod

1.044

0.767, 1.320

< 0.001

1.047

0.770, 1.323

< 0.001

 • Glatiramer Acetate

−0.082

−0.187, 0.024

0.131

−0.079

−0.185, 0.027

0.142

 • Mycophenolate

−0.072

−0.181, 0.037

0.197

−0.075

− 0.184, 0.035

0.181

 • Natalizumab

−0.529

−0.647, − 0.411

< 0.001

−0.526

− 0.644, − 0.408

< 0.001

 • Other

− 0.009

−0.141, 0.124

0.900

−0.012

− 0.144, 0.121

0.862

CES-D

0.034

0.008, 0.061

0.012

0.030

0.004, 0.055

0.022

MFIS

0.045

0.012, 0.078

0.008

0.035

0.004, 0.066

0.029

MSSS

−0.019

−0.047, 0.010

0.203

−0.021

−0.048, 0.006

0.121

SF-36 Physical QOL

−0.055

−0.086, − 0.024

< 0.001

−0.037

− 0.067, − 0.007

0.015

SF-36 Mental QOL

− 0.024

−0.050, 0.003

0.086

−0.024

− 0.049, 0.002

0.066

  1. Legend: CES-D Center for epidemiology scale for depression, MFIS Modified fatigue impact scale, MSSS Modified social support survey, QOL Quality of life, BMI Body mass index, DMT Disease modifying therapy. Mixed linear regression models use data from all patient visits (repeated measures), with multivariable model including the following covariates: age, gender, smoking history, and DMT use. Continuous predictor variables are Z-transformed such that one unit increase represents one standard deviation change. Bolded values represent p < 0.05