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Fig. 1 | BMC Neurology

Fig. 1

From: A novel nonsense mutation in WNK1/HSN2 associated with sensory neuropathy and limb destruction in four siblings of a large Iranian pedigree

Fig. 1

The pedigree and clinical appearance of the studied family. a Iranian HSAN2A pedigree with a mutation in WNK1/HSN2 gene. Genotypes of studied individuals are presented. Filled circles and squares, affected individuals; unfilled circles and squares, unaffected members; Arrow shows proband. M, mutated allele; N, normal allele; B, C. Chronic ulcers as well as the amputated and mutilated sites on upper and lower extremities of the HSAN2-IV: 11 (b) and HSAN2-IV: 12 (c). D, E. Fingers deformity and Charcot joint in the left foot of the patients HSAN2-IV: 13 (d) and HSAN2-IV: 14 (e)

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BMC Neurology

ISSN: 1471-2377

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