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Fig. 3 | BMC Neurology

Fig. 3

From: Targeting the Notch1 oncogene by miR-139-5p inhibits glioma metastasis and epithelial-mesenchymal transition (EMT)

Fig. 3

Notch1 knockdown suppressed metastasis and invasion capability of glioma cells. (a and b) qRT-PCR represented Notch1 expression levels in the LN229 and U87 cells transfected with different quantity of siRNA and lipofectamine2000 (μL. the concentration of siRNA was 20 μM). (c and e) Wound healing assays confirmed that Notch1 siRNA suppressed the migration of LN229 cells. (× 50 magnification). (d and f) Wound healing assays confirmed that Notch1 siRNA suppressed the migration of U87 cells. (× 50 magnification). (g and i) Representative images and histograms of in vitro transwell assays of LN229 after transfected with Notch1 siRNA and control. (× 50 magnification). (h and j) Representative images and histograms of in vitro transwell assays of U87 after transfected with Notch1 siRNA and control. (× 50 magnification). (*P < 0.05. **P < 0.01. ***P < 0.001)

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