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Table 3 Univariate linear regression analysis: ORs and 95% CIs for CAN in T1 DM and T2 DM patients

From: Cardiac autonomic neuropathy in type 1 and type 2 diabetes patients

CAN in T1DM patients

CAN in T2DM patients

Variable

OR (CI 95%)

p-value

OR (CI 95%)

p-value

 Male/Female, nr (%)

0.80 (0.18–3.37)

0.76

0.92 (0.49–1.75)

0.81

 Age (years)

1.14 (1.03–1.27)

0.0009

1.02 (0.98–1.06)

0.22

 Age at DM diagnosis (years)

0.93 (0.83–1.03)

0.17

0.89 (0.85–0.94)

< 0.0001

 DM duration (years)*

1.62 (1.13–2.31)

0.0007

1.67 (1.42–1.92)

0.0001

 BMI (kg/m2)

1.19 (0.96–1.48)

0.09

1.16 (1.08–1.24)

0.0003

 SBP (mmHg)

1.04 (0.98–1.10)

0.16

1.01 (1.00–1.03)

0.02

 DBP(mmHg)

1.01 (0.96–1.10)

0.38

1.004 (0.97–1.03)

0.44

 Hypertension (yes)

7.38 (0.80–68.1)

0.07

1.34 (0.68–2.68)

0.39

 Smoking (yes vs. no)

0.62 (0.15–2.61)

0.52

2.35 (1.23–4.49)

0.0009

 Cholesterol (mg%)

1.01 (0.98–1.04)

0.14

1.01 (1.00–1.01)

0.004

 Triglyceride (mg%)

1.01 (0.99–1.02)

0.16

1.00 (0.99–1.00)

0.03

 HgbA1c

4.49 (1.27–15.9)

0.01

1.74 (1.34–2.27)

< 0.0001

 FPG (mg%)

1.01 (0.99–1.01)

0.85

1.00 (1.00–1.01)

0.01

 eRFG (ml/min/1.73 m2)

0.94 (0.89–0.99)

0.007

0.91 (0.88–0.93)

< 0.0001

 ABI

1.13 (0.01–76.01)

0.95

0.01 (0.00–0.20)

0.001

 QTc

1.05 (1.01–1.1)

0.007

1.20 (1.03–1.07)

< 0.0001

 IMT

5.5 (2.3–8.3)

0.007

10.12 (7.21–15.32)

< 0.0001

 RD (yes vs no)

1.25 (0.56–1.9)

0.88

13.13 (3.03–84.73)

0.002

 PNP (yes vs no)

31.6 (4.5–45.8)

0.001

25.94 (11.04–44.25)

0.0001

  1. BP- blood pressure, FPG - fasting plasma glucose, HgbA1c-glycosylated hemoglobine, eGFR - estimated glomerular filtration rate, PNP- peripheral neuropathy, ABI- ankle-brachial index, IMT - intima-media thickness, QTc- corrected QT interval, *- median range