Table 3 Course of symptom severity, restless legs syndrome, and pain throughout the BETASLEEP study
Characteristic | Baseline visit | 6-month visit | 12-month visit | 18-month visit | 24-month visit | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
All Patients | Good sleepers (PSQI< 5) | Poor sleepers (PSQI≥5) | All Patients | Good sleepers (PSQI< 5) | Poor sleepers (PSQI≥5) | All Patients | Good sleepers (PSQI< 5) | Poor sleepers (PSQI≥5) | All Patients | Good sleepers (PSQI< 5) | Poor sleepers (PSQI≥5) | All Patients | Good sleepers (PSQI< 5) | Poor sleepers (PSQI≥5) | |
EDSS | N = 128 | N = 35 | N = 71 | N = 90 | N = 26 | N = 50 | N = 75 | N = 25 | N = 40 | N = 50 | N = 16 | N = 27 | N = 49 | N = 17 | N = 25 |
Median (range) | 2.0 (0.0–5.0) | 2.0 (0.0–5.0) | 2.0 (0.0–5.0) | 2.0 (0.0–6.5) | 2.0 (0.0–4.0) | 2.0 (0.0–6.5) | 2.0 (0.0–6.5) | 1.5 (0.0–4.5) | 2.0 (0.0–6.5) | 2.0 (0.0–6.5) | 1.5 (0.0–4.5) | 2.0 (0.0–6.5) | 2.0 (0.0–5.0) | 1.5 (0.0–5.0) | 2.0 (0.0–5.0) |
MSFC | N = 93 | N = 26 | N = 55 | N = 54 | N = 18 | N = 31 | N = 31 | N = 8 | N = 17 | ||||||
Median (range) | 0.11 (− 3.46–1.49) | 0.21 (− 1.01–0.69) | 0.08 (− 3.46–1.49) | 0.20 (− 1.13–0.87) | 0.26 (− 0.76–0.87) | 0.22 (− 1.13–0.80) | 0.17 (− 1.52–0.99) | 0.20 (− 0.46–0.73) | 0.17 (− 1.52–0.99) | ||||||
RLS, evaluable patients (N) | N = 128 | N = 35 | N = 67 | N = 109 | N = 33 | N = 59 | N = 96 | N = 31 | N = 50 | N = 65 | N = 20 | N = 34 | N = 61 | N = 20 | N = 31 |
n (%) | 5 (3.9) | 0 | 4 (6.0) | 3 (2.8) | 0 | 2 (3.4) | 4 (4.2) | 0 | 2 (4.0) | 1 (1.5) | 0 | 1 (2.9) | 2 (3.3) | 0 | 2 (6.5) |
HSAL | N = 7 | N = 1 | N = 5 | N = 6 | N = 1 | N = 3 | N = 5 | N = 1 | N = 2 | N = 4 | N = 1 | N = 2 | N = 3 | N = 0 | N = 2 |
Median (range) | 111.0 (18–193) | 18.0 (18–18) | 111.0 (38–193) | 42.5 (0–151) | 0.0 (0–0) | 50.0 (6–133) | 48.0 (0–89) | 0.0 (0–0) | 62.5 (48–77) | 61.5 (0–109) | 0.0 (0–0) | 61.5 (30–93) | 124.0 (26–137) | – | 75.0 (26–124) |