EDSS 0–3.5 n = 152 | EDSS 4.0–10 n = 70 | Total n = 222 | p-value | |
---|---|---|---|---|
Mean age, years (SD) | 42.5 (11.5) | 52.2 (12.2) | 45.5 (12.5) | <0.001 |
Gender, female, % | 68.4 | 65.7 | 64.4 | 0.292 |
Mean time since diagnosis, years (SD) | 10.5 (7.6) | 19.8 (10.2) | 13.4 (9.5) | <0.001 |
MS type, % | ||||
RRMS | 74.3 | 35.7 | 62.2 | <0.001 |
SPMS | 13.8 | 50.0 | 25.2 | <0.001 |
PPMS | 7.2 | 14.3 | 9.5 | 0.094 |
CIS | 4.6 | 0.0 | 3.2 | 0.001 |
Overall comorbidity, mean (SD) | ||||
Number of comorbidities | 4.5 (2.7) | 6.0 (3.3) | 5.0 (3.0) | 0.001 |
Charlson Index | 0.7 (0.6) | 1.0 (0.7) | 0.8 (0.6) | 0.005 |
RUBs | 2.9 (0.8) | 3.2 (0.7) | 3.0 (0.8) | 0.003 |
Comorbid diagnoses, % | ||||
Depression | 34.2 | 28.6 | 32.4 | 0.404 |
Dyslipidaemia | 25.7 | 42.9 | 31.1 | 0.010 |
Hypertension | 17.8 | 34.3 | 23.0 | 0.007 |
Obesity | 22.4 | 22.9 | 22.5 | 0.935 |
Active smoking | 16.4 | 12.9 | 15.3 | 0.490 |
Neoplasm | 9.2 | 15.7 | 11.3 | 0.154 |
COPD | 6.6 | 14.3 | 9.0 | 0.062 |
Diabetes mellitus | 6.6 | 10.0 | 7.7 | 0.373 |
Asthma | 7.9 | 2.9 | 6.3 | 0.151 |
Ischemic stroke | 4.6 | 8.6 | 5.9 | 0.242 |
Alcoholism | 3.9 | 5.7 | 4.5 | 0.555 |
Ischemic cardiomyopathy | 2.6 | 8.6 | 4.5 | 0.047 |