Relationship between Azathioprine metabolites and therapeutic efficacy in Chinese patients with neuromyelitis optica spectrum disorders

Table 4 The linear- regression between multiple variables and ARR improvements (in log)

Variable	Standardized coefficients- Beta	T	P-value
Constant (SE)	0.417 (0.116)	3.580	0.002
Normalized Concentration of 6-TGNs	−0.489	−2.689	0.013*
Excluded variables
Age of onset, year	0.156	0.853	0.403
Disease duration, months	0.094	0.509	0.616
Treatment duration, months	−0.200	−1.106	0.281
Pre-therapy EDSS score	0.034	0.176	0.862
Post-therapy EDSS score	0.050	0.266	0.793
Mean CSF protein, mg/dl	−0.038	−0.198	0.845
Mean Concentration of CSF IgG, mg/ml	−0.158	−0.855	0.402
CSF IgG index (n%)	−0.287	−1.636	0.116
Normalized Concentration of MMPNs	−0.150	−0.751	0.461

NMOSD, AZA Azathioprine, BMI Body mass index, ARR Annual relapse rate, EDSS Expanded disability status scale, 6-TGN 6-thioguanine nucleotides, 6-MMPN 6-methylmercaptopurine nucleotides. All P-value <0.05 was considered statistically significant