Clinical indices | MRI features |
---|---|
• Age at disease onset | Cortical thickness |
• Site of disease onset |  • Precentral gyri |
• Diagnostic delay |  • Paracentral gyri |
• Disease severity ALSFRS-r | White matter  • Superior corona radiata |
 • Inferior corona radiata | |
 • Anterior limbs of the internal capsule | |
 • Posterior limbs of the internal capsule | |
 • Cerebral peduncles | |
 • Genu of the corpus callosum | |
 • Body of the corpus callosum | |
 • Splenium of the corpus callosum |