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Table 5 Second- and third-degree AV blocks during treatment initiation

From: Electrocardiographic assessments and cardiac events after fingolimod first dose – a comprehensive monitoring study

 

Fingolimod 0.5 mg N = 3951

Patients with 12-lead ECG recording, n

N = 3951

 Patients with first-degree AV block, n (%)

280 (7.1)

 Pre-dose

96 (2.7)

 Post-dose

206 (5.8)

Patients with Holter ECG recording, n

N = 3906

 Patients with second-degree AV block, n (%)

62 (1.6)

 Mobitz Type I (Wenckebach)

60 (1.5)a

 2:1

18 (0.5)a

 Mobitz Type II (Mobitz)

0

 Patients with third-degree AV block, n (%)

0

  1. aA patient might experience both Mobitz type I and 2:1 AV blocks during the six-hour monitoring