Bone mineral density in patients with multiple sclerosis, hereditary ataxia or hereditary spastic paraplegia after at least 10 years of disease - a case control study

Table 4 Comparing biochemical measures in MS patients and control patients (HSP/HA) with P-values, both unadjusted and adjusted

	MS	HSP/HA	Unadjusted β (95%CI)	P-value	Adjusted β (95%CI)	P-value
25(OH)D	77.5 ± 28.9	70 ± 26.2	−7.5 (15.9, 1.0)	0.08	−7.5 (15.9, 1.0)	0.08
1,25(OH) ₂D	139.8 ± 55.9	129.0 ± 36.2	−10.8 (−25.4, 3.9)	0.2	−10.8 (−25.4, 3.9)	0.2
PTH	3.7 ± 2.0	4,7 ± 2.0	1.0 (0.4,1.6)	0.002	0.17 (−0.6,1.0)	0.7*
iCa	1.3 ± 0.1	1.3 ± 0.1	0.0 (−0.01, 0.01)	0.8	0.0 (−0.01, 0.01)	0.8
Phosphate	1.1 ± 0.2	1.0 ± 0.2	−0.1 (−1.2, 0.02)	0.009	0.0 (−0.1, 0.1)	0.8**
DBP	4.2 ± 0.6	4.3 ± 0.8	0.1 (−0.1, 0.3)	0.5	0.1 (−0.1, 0.3)	0.5
Creat	67.7 ± 12.8	70.6 ± 14.4	2.9 (−1.3, 7.0)	0.2	2.9 (−1.3, 7.0)	0.2
bALP	23.4 ± 8.2	25.0 ± 6.1	1.6 (−0.6, 3.8)	0.2	1.6 (−0.6, 3.8)	0.2
NTX	46.8 ± 20.9	54.1 ± 36.3	7.3 (−1.7, 16.2)	0.1	7.3 (−1.7, 16.2)	0.1
Total Ca	2.4 ± 0.1	2.4 ± 0.1	0.0 (−0.01, 0.01)	0.9	0.0 (−0.01, 0.01)	0.9
Albumin	44.9 ± 2.4	45.3 ± 2.5	0.4 (−0.4, 1.1)	0.3	0.4 (−0.4, 1.1)	0.3
TSH	1.3 ± 0.7	1.3 ± 0.6	0.0 (−0.2, 0.2)	0.9	−0.0 (−0.2, 0.2)	0.9

Some variables have missing values due to technical errors (number of missing patients in parentheses): iCalcium (2), total Ca (2), phosphate (3), creatinin (3), albumin (3), thyroid stimulating hormone (TSH) and NTX (2) from MS patients and PTH (1), iCa (1), total Ca (1), phosphate (2), albumin (1) and NTX (2) from HA/HSP patients
Abbreviations: 25(OH)D 25-hydroxyvitamin D, 1,25(OH)₂D 1,25-dihydroxyvitamin D (active vitamin D metabolite), PTH parathyroid hormone, iCa ionized calcium, DBP vitamin D binding protein, bALP bone specific alkaline phosphatase, NTX cross linked N-terminal telopeptide of type 1 collagen, Ca calcium, TSH thyroid stimulating hormone
*Adjusted for corticosteroid use, disease duration and alcohol use
**Adjusted for corticosteroid and BMI

ISSN: 1471-2377