A regional consensus recommendation on brain atrophy as an outcome measure in multiple sclerosis

BMC Neurology

Table 5 The tally of brain volume assessment

How?	SIENA	SIENAx	BPF	VBM
How?	12	4
In Whom?	RIS	CIS	RRMS	SPMS
In Whom?	7	11	12	4
When?	Initial	3–6 months	Anytime with MRI acquisition	6–12 months	Annual
When?	3		2	11	1
Who?	Neurologist	Radiologist	MRI Technician	Independent
Who?		1	12	1

Abbreviations: BPF (Brain Parenchymal Fraction), SIENA (Structural Image Evaluation, using Normalization, of Atrophy), SIENAx (Structural Image Evaluation, using Normalization, of Atrophy Cross-sectional), VBM (Voxel-Based Morphometry)

ISSN: 1471-2377