Table 1 A list of unmet needs with brain volume as identified by the panel
From: A regional consensus recommendation on brain atrophy as an outcome measure in multiple sclerosis
Unmet Needs | |
|---|---|
1. | Applicability of MRI volume measurement in clinical practice |
2. | Lack of large long-term prospective studies of clinical correlates with brain volume loss |
3. | Reliable assessments of cognitive impairment in MS |
4. | Validation of disease progression parameters with brain volume loss |
5. | Lack of pathological correlation with brain volume loss |
6. | Paucity of data on regional brain volume effect in MS |
7. | Targeting brain volume loss as one of the main outcome measure in clinical trials |
8. | Reproducible effectiveness of DMTs in phase III studies on cognitive impairment |