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Fig. 1 | BMC Neurology

Fig. 1

From: Dissociation of amyloid biomarkers in PET and CSF in Alzheimer’s disease: a case report

Fig. 1

Imaging biomarkers for Alzheimer’s disease. Atrophy was evident in magnetic resonance imaging (MRI) in temporal/hippocampal regions in T1 (a) and T2 (b) sequence, and in parietal cortex in T1 (c). Single white matter lesions were detected in fast fluid-attenuated inversion recovery (FLAIR) images (d). Amyloid positron emission tomography (PET) with [18F]florbetaben did not show specific binding in the neocortical gray matter (e), although hypometabolism was detected in bilateral parietotemporal and posterior cingluate cortices with [18F]fluorodeoxyglucose-PET (f). Finally, we evaluated statistical deviation of tracer uptake from a normal control group including 94 (amyloid) or 25 (glucose) normal subjects with the Hermes Brass Software. Z score map of the [18F]florbetaben PET (g) did not show relevant (z score > 2.5) cortical tracer uptake increase, whereas the z score map of [18F]fluorodeoxyglucose-PET (h) showed relevant (z score > 2.5) tracer uptake reduction in bilateral parietotemporal regions and posterior cingulate cortices

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