Study | Annualized relapse rate (Number of relapses/year) | EDSS score impact | MRI impact | Study duration | ||
---|---|---|---|---|---|---|
NAb+ | NAb- | p | ||||
IFN β Multiple Sclerosis Study Group, University of British Columbia MS/MRI Analysis Group, Neurology 1996 [ [2]] | 1.16 | 0.50 | < 0.05 | Positive impact | Yes | 3 years |
Ruddick et al., Neurology 1998 [ [4]] | 0.50 | 0.65 | NS | No impact | Yes | 2 years |
PRISMS Study Group, Lancet 1998 [ [5]] | 1.75 | 1.74 | _ | _ | _ | 2 years |
Panitch et al., Neurology 2002 [ [8]] | _ | _ | NS | _ | Yes | 48 weeks |
Sorensen et al., Lancet 2003 [ [9]] | 0.64 | 0.43 | < 0.03 | No impact | _ | _ |
Malucchi et al., Neurology 2004 [ [10]] | 0.85 | 0.53 | 0.039 | Negative impact | _ | 3 years |
Francis et al., Neurology 2005 [ [17]] | 0.85 | 0.52 | < 0.001 | No impact | Yes | 4 years |
Kappos et al., Neurology 2005 [ [18]] | 0.97 | 0.70 | 0.04 | No impact | Yes | 4 years |
Freedman et al., Multiple Sclerosis 2005 [ [11]] | _ | _ | NS | No impact | Yes | 3 years |
Hartung et al., Neurology 2011 [ [12]] | _ | _ | 0.39 | No impact | Yes | 5 years |
Sato et al., Tokohu J Exp Med 2012 [ [14]] | _ | _ | 0.13 | _ | Yes | _ |