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Table 1 Summary of study characteristics of studies included in this literature review

From: Hypopituitarism after subarachnoid haemorrhage, do we know enough?

 

Study design

Inclusion criteria

Exclusion criteria

Selection bias

Lost to FU nr

Dynamic tests

Analysis

Results

Aimaretti et al. [37]

Prospective cohort

-

-

yes

0

GHRH-arg

+

+

Brandt et al. [33]

Case series

+

+

yes

0

TRH test & ITT (7 out of 10 pts)

+

+

Dimopoulou et al. [17]

Retrospective cohort

+

+

yes

0

none

+

+

Kreitschmann-Andermahr et al. [35]

Retrospective cohort

+

+

yes

10

TRH-LHRH test & ITT

+

+

Aimaretti et al. [32]

Prospective cohort

-

-

yes

0

GHRH-arg

+

+

Kreitschmann- Andermahr et al. [36]

Case series

+

+

yes

8

ITT (14 out of 45 pts)

+

+

Jovanovic et al. [34]

Case series

+

+

yes

0

none

+

+

Tanriverdi et al. [39]

Prosective cohort

+

+

no

0

GHRH-arg & glucagon test

+

+

Klose et al. [40]

Prospective cohort

+

+

no

0

ITT (GHRH-arg if contraindicated)

+

+

Lammert et al. [38]

Prospective cohort

+

+

yes

4

ACTH stimulation test (ITT in some patients)

+

+

Dutta et al. [46]

Retrospective cohort

+

+

yes

0

none

+

+

Gardner et al. [41]

Prospective cohort

+

+

no

0

GHRH-arg and glucagon test

+

+

Khursheed et al. [43]

Prospective cohort

+

+

no

0

none

+

+

Kronvall et al. [44]

Prospective cohort

+

+

no

6

GHRH-arg

no

no

Karaca et al. [45]

Prospective cohort

+

+

no

2

Glucagon test

+

+

Blijdorp et al. [42]

Prospective cohort

+

+

yes

0

Ghrelin test and GHRH-arg, Synacten test in some patients

+

+

  1. +: inclusion criteria, exclusion criteria, assessment methods and results clearly defined and reflected, -: inclusion criteria, exclusion criteria, assessment methods and results not or not clearly defined.
  2. GHRH- arg test: growth hormone releasing hormone plus arginine test, ITT: insulin tolerance test, d: TRH: thyrotropin releasing hormone, ACTH: adrenocorticotropic hormone, LHRH: gonadotropin releasing hormone, lost to FU number: number of patients lost in follow up of studies with more than one measurement overtime.