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Table 1 Univariate analysis of potential prognostic factors associated with mortality one year after first diagnosis (N = 176)

From: Factors predicting one-year mortality in amyotrophic lateral sclerosis patients - data from a population-based registry

Parameters at FD

N

Category

Total

Death during 12 months from FD

Log-rank test

ob-served

mis-sing

n = 60

%

X2(DF)

p(X2)

Age

176

0

≤ 65

69

18

26%

24.13 (2)

< 0.0001

66-75

84

25

30%

> 75

23

17

74%

Gender

176

0

male

96

31

32%

0.29 (1)

0.59

female

80

29

36%

Site of onset

176

0

bulbar

62

25

40%

1.71 (1)

0.19

spinal

114

35

31%

Site of spinal onset

114

0

upper limbs

39

10

26%

2.58 (4)

0.64

lower limbs

60

20

33%

upper + lower limbs

8

3

38%

trunk

7

2

29%

DOD [months]

176

0

0 - 6

60

27

45%

9.41 (3)

0.024

07-12

61

17

28%

13-24

37

15

41%

≥ 25

18

1

6%

BMI [kg/ m 2 ]

173

3

< 25

92

34

37%

0.97 (1)

0.33

≥ 25

81

24

30%

Diff-BMI [kg/ m 2 ]

173

3

< 1

87

14

16%

33.14 (2)

< 0.0001

1 - < 2

31

11

35%

≥ 2

55

33

60%

EEC

176

0

possible

31

6

19%

16.21 (3)

0.001

probable (lab. conf.)

54

12

22%

probable

63

26

41%

definite

28

16

57%

FRS

173

3

< 32

72

44

61%

46.92 (1)

< 0.0001

≥ 32

101

14

14%

FVC [%]

153

23

< 80

31

19

61%

28.61 (1)

< 0.0001

≥ 80

122

27

22%

PCO 2 [mm Hg]

134

42

< 42

112

33

29%

15.97 (1)

< 0.0001

≥ 42

22

14

64%

CK [U/ l]

153

23

< 150

73

27

37%

1.29 (1)

0.26

≥ 150

80

24

30%

Pre-alcohol cons. status

149

27

no

62

26

42%

2.99 (1)

0.084

yes

87

19

22%

Pre-smoking status

151

25

no

85

23

27%

0.69 (1)

0.41

yes

66

23

35%

social life

153

23

living in a partnership

109

28

26%

1.59 (1)

0.21

single person

44

19

43%

Abbreviations

DOD

delay between onset and diagnosis

FD

first diagnosis

BMI

body mass index

FRS

functional rating scale

Diff-BMI

difference between BMI at diagnosis and six months before

FVC

forced vital capacity

  

PCO2

carbondioxide pressure in blood

EEC

revised El Escorial criteria

CK

creatinine kinase