Subgroups patients | ||||||
---|---|---|---|---|---|---|
B-SIT | SSIT | |||||
Characteristics | Controls n = 30 | Patients n = 18 | >50% score n = 6 | ≤50% score n = 12 | >50% score n = 10 | ≤50% score n = 6 |
Demographic data | ||||||
Gender (female/male%) | 46.7/53.3 | 55.6/44.4 | 66.7/33.3 | 50.0/50.0 | 70.0/30.0 | 16.7/83.3+ |
Age (years) | 67.4 ± 7.6 | 74.6 ± 6.3** | 76.0 ± 7.8 | 73.8 ± 5.7 | 76.5 ± 1.3 | 72.3 ± 5.1 |
Education (years) | 17.1 ± 3.5 | 15.3 ± 2.5 | 15.3 ± 1.3 | 15.3 ± 3.0 | 14.8 ± 1.9 | 16.8 ± 3.4 |
Daily smokers (%) | 3.3 | 5.6 | 0 | 8.3 | 0 | 0 |
APOE Ɛ4 genotype (% carriers 1-2 alleles) | 20.8 | 73.3** | 75.0 | 72.7 | 62.5 | 83.3 |
Cognitive tests | ||||||
MMSE (max. score 30) | 28.7 ± 1.2 | 25.5 ± 2.5** | 26.0 ± 1.7 | 25.3 ± 2.8 | 26.0 ± 1.6 | 25.7 ± 3.0 |
Ten-word test, total recall (max. score 30) | 22.7 ± 3.6 | 12.5 ± 3.8** | 13.2 ± 3.7 | 12.1 ± 3.9 | 12.1 ± 3.6 | 14.0 ± 4.2 |
Ten-words tests, delayed recall (max. 10) | 8.1 ± 1.9 | 2.2 ± 1.7** | 3.2 ± 1.8 | 1.6 ± 1.4 | 2.5 ± 1.9 | 1.8 ± 1.5 |
RCFT, figure copying | 30.9 ± 3.0 | 26.0 ± 5.1** | 24.6 ± 4.6 | 26.8 ± 5.4 | 23.9 ± 4.3 | 29.8 ± 4.4+ |
RCFT, immediate recall | 17.9 ± 5.6 | 6.3 ± 4.4** | 6.2 ± 6.1 | 6.4 ± 3.5 | 6.0 ± 4.6 | 6.8 ± 4.6 |
RCFT, delayed recall | 17.7 ± 5.3 | 6.9 ± 4.2** | 7.2 ± 6.8 | 6.7 ± 2.0 | 7.5 ± 4.8 | 5.9 ± 3.5 |
Stereognosis (max. score 12) | 11.5 ± 0.8 | 10.2 ± 2.2** | 10.2 ± 1.6 | 10.2 ± 2.6 | 10.6 ± 1.4 | 9.5 ± 3.2 |
Trail Making A (sec) | 52.6 ± 20.1 | 64.7 ± 21.8 | 61.2 ± 15.9 | 64.2 ± 24.5 | 66.0 ± 21.4 | 66.7 ± 25.7 |
Trail Making-B (sec) | 104.1 ± 37.5 | 134.0 ± 51.8* | 141.0 ± 58.9 | 127.0 ± 48.3 | 148.3 ± 47.7 | 126.3 ± 56.2 |
Phychophysical mesurements | ||||||
B-SIT (12 items) | 9.6 ± 2.0 | 6.6 ± 2.6** | 9.8 ± 1.6 | 5.0 ± 0.7## | 7.4 ± 2.6 | 5.7 ± 2.7 |
SSIT (16 items) | 12.7 ± 2.4 | 9.4 ± 3.0** | 11.3 ± 3.1 | 8.2 ± 2.3# | 11.1 ± 2.1 | 6.5 ± 1.8+ |
SSDT (16 items) | 9.2 ± 3.3 | 7.5 ± 3.0 | 7.8 ± 3.4 | 7.3 ± 3.0 | 7.4 ± 2.9 | 7.6 ± 3.5 |