Table 2 Laboratory features between NMOSD without and with autoimmune diseases, and between NMOSD with non-organ-specific and organ-specific autoimmune diseases

CSF Index

WBC (10⁶)

6 (0, 140)

10 (0, 48)

0.002*

12 (2, 48)

9.5 (0, 46)

0.307

Protein (g/l)

0.22 (0.06, 1.64)

0.27 (0.12, 0.80)

0.017*

0.27 (0.19, 0.80)

0.32 (0.12, 0.72)

0.754

Glucose (mmol/l)

3.47 ± 0.70

3.11 ± 0.94

0.012*

2.88 ± 0.23

3.41 ± 1.59

0.075

Chloride (mmol/l)

126.3 ± 5.1

126.6 ± 2.8

0.657

126.3 ± 6.9

127.0 ± 9.7

0.434

OCB, n (%)

6 (5.2%)

3 (7.5%)

0.595

2 (9.1%)

1 (5.6%)

1.000

Serums Index

CRP (mg/l)

2.33 ± 4.37

5.63 ± 7.62

0.001*

2.16 (0.00, 26.09)

0.80 (0.10, 15.00)

0.289

ESR (mm/H)

12.90 ± 7.89

14.04 ± 13.39

0.519

10.5 (1.3, 50.0)

7.00 (3.0, 24.0)

0.414

NMO-IgG, n (%)

71 (67.0%)

32 (80.0%)

0.120

18 (81.8%)

14 (77.8%)

0.751

ANA, n (%)

16 (13.9%)

20 (50.0%)

<0.001**

18 (81.8%)

2 (11.1%)

<0.001**

SSA, n (%)

2 (1.7%)

20 (50.0%)

<0.001**

20 (90.9%)

0 (00.0%)

<0.001**

SSB, n (%)

1 (0.9%)

11 (27.5%)

<0.001**

11 (50.0%)

0 (00.0%)

0.002*

RF, n (%)

2 (1.7%)

3 (7.5%)

0.075

2 (9.10%)

1 (5.60%)

1.000

Ds-DNA, n (%)

0 (0.0%)

5 (12.5%)

0.001*

5 (22.7%)

0 (00.0%)

0.053

AnuA, n (%)

0 (0.0%)

3 (7.5%)

0.021*

3 (13.6%)

0 (00.0%)

0.305

AHA, n (%)

0 (0.0%)

1 (2.5%)

0.579

1 (4.5%)

0 (00.0%)

1.000

RNP, n (%)

0 (0.0%)

2 (5.0%)

0.110

2 (9.1%)

0 (00.0%)

0.492

Sm, n (%)

0 (0.0%)

3 (7.5%)

0.021*

3 (13.6%)

0 (00.0%)

0.305

Jo-1, n (%)

0 (00.0%)

0 (00.0%)

-

0 (00.0%)

0 (00.0%)

-

Scl-70, n (%)

0 (00.0%)

0 (00.0%)

-

0 (00.0%)

0 (00.0%)

-

ANCA, n (%)

0 (00.0%)

0 (00.0%)

-

0 (00.0%)

0 (00.0%)

-

Rib-P, n (%)

0 (0.0%)

2 (5.0%)

0.110

2 (9.1%)

0 (00.0%)

0.492

AKA, n (%)

0 (00.0%)

0 (00.0%)

-

0 (00.0%)

0 (00.0%)

-

RA33, n (%)

0 (00.0%)

0 (00.0%)

-

0 (00.0%)

0 (00.0%)

-

CCP, n (%)

0 (00.0%)

0 (00.0%)

-

0 (00.0%)

0 (00.0%)

-

IgG (g/l)

12.46 ± 4.95

18.33 ± 0.82

<0.001**

14.18 (7.00, 38.80)

12.61 (7.00, 33.22)

0.765

IgA (g/l)

1.41 ± 0.40

1.51 ± 4.95

0.310

1.30 (0.45, 3.60)

1.28 (0.56, 2.15)

0.142

IgM (g/l)

1.15 ± 0.37

1.06 ± 0.38

0.169

1.14 (0.45, 1.75)

0.97 (0.58, 1.99)

0.454

C3 (g/l)

1.09 ± 0.24

1.04 ± 0.39

0.334

1.06 ± 0.17

1.01 ± 0.13

0.667

C4 (g/l)

0.23 ± 0.15

0.19 ± 0.15

0.116

0.15 (0.04, 0.93)

0.15 (0.03, 0.32)

0.935

CH50 (U/ml)

44.11 ± 12.80

39.60 ± 17.12

0.082

41.50 (10.00, 66.00)

33.00 (19.00, 61.00)

0.549

TPO (U/ml)

54.46 ± 72.57

86.02 ± 124.90

0.055

29.3 (5.7, 60.0)

99.9 (11.7, 533.1)

0.019*

TG (U/ml)

42.82 ± 54.46

91.83 ± 127.25

0.001*

34.05(10.11, 97.14)

82.10 (1.99, 500.00)

0.003*

T3 (nmol/l)

1.96 ± 1.60

4.01 ± 13.72

0.114

1.99 (0.66, 2.45)

1.20 (0.70, 88.08)

1.000

T4 (nmol/l)

97.47 ± 25.95

120.95 ± 65.17

0.002*

106.5 (76.9, 170.0)

94.8 (11.7, 363.6)

0.765

FT3 (pmol/l)

4.07 ± 0.97

4.45 ± 3.31

0.273

4.16 (2.59, 5.47)

3.89 (1.03, 23.98)

0.903

FT4 (pmol/l)

15.62 ± 4.67

20.21 ± 15.91

0.006*

17.06 (10.89, 22.92)

17.18 (8.60, 99.25)

0.663

TSH (uIU/ml)

1.91 ± 2.48

2.85 ± 6.05

0.169

1.93 (0.42, 4.02)

0.98 (0.01,36.50)

0.149