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Table 3 Central and variation measures for ADAS-Cog items and sumscores for the seven assessments

From: Changes in cognitive domains during three years in patients with Alzheimer's disease treated with donepezil

Test

Max error

Study entry

6 months

12 months

18 months

24 months

30 months

36 months

ADAS-Cog Items

Word Recall

10

6 (5, 7)

6 (5, 7)

6 (5, 7)

7 (5, 8)

6 (5, 8)

7 (5, 8)

7 (5, 8)

Naming

5

0 (0, 1)

0 (0, 1)

0 (0, 1)

0 (0, 1)

0 (0, 1)

0 (0, 1)

0 (0, 1)

Delayed Word Recalla

10

9 (7, 10)

9 (7, 10)

9 (7, 10)

10 (7, 10)

9 (7, 10)

10 (8, 10)

10 (8, 10)

Commands

5

0 (0, 1)

0 (0, 1)

0 (0, 1)

1 (0, 1)

1 (0, 2)

1 (0, 2)

1 (0, 2)

Constructional Praxis

5

1 (0, 1)

1 (0, 1)

1 (0, 1)

1 (0, 1)

1 (0, 2)

1 (0, 2)

1 (0, 3)

Ideational Praxis

5

0 (0, 1)

0 (0, 1)

0 (0, 1)

0 (0, 1)

0 (0, 1)

0 (0, 1)

0 (0, 2)

Orientation

8

1 (0, 3)

1 (0, 3)

2 (1, 4)

2 (0, 4)

3 (1, 4)

3 (1, 5)

4 (1, 5)

Word Recognition

12

5 (3, 8)

5 (3, 8)

5 (3, 9)

5 (3, 9)

6 (3, 9)

6 (3, 9)

8 (5, 11)

Remembering Test Instr.

5

1 (0, 1)

1 (0, 1)

1 (0, 2)

1 (0, 2)

1 (0, 3)

1 (0, 3)

1 (0, 3)

Spoken Language Ability

5

0 (0, 1)

0 (0,1)

0 (0, 1)

0 (0, 1)

0 (0, 1)

0 (0, 1)

0 (0, 1)

Word-finding Difficulty

5

1 (0, 1)

1 (0, 1)

0 (0, 1)

1 (0, 1)

1 (0, 1)

1 (0, 1)

1 (0, 2)

Comprehension

5

0 (0, 1)

0 (0, 1)

0 (0, 1)

0 (0, 2)

0 (0, 1)

1 (0, 2)

1 (0, 2)

Concentrationa

5

0 (0, 1)

0 (0, 1)

0 (0, 1)

0 (0, 1)

0 (0, 2)

0 (0, 1)

0 (0, 1)

ADAS-Cog Sumscores

ADAS-Cog, men

70

17.5 ± 10.0

16.6 ± 9.44

17.7 ± 11.6

19.3 ± 13.3

20.4 ± 14.3

21.5 ± 15.9

23.6 ± 18.0

ADAS-Cog, women

70

18.7 ± 8.45

19.1 ± 8.99

20.4 ± 10.2

22.5 ± 11.6

23.7 ± 11.6

26.3 ± 14.1

29.5 ± 15.7

ADAS-Cog, total

70

18.2 ± 9.03

18.2 ± 9.21

19.5 ± 10.7

21.4 ± 12.3

22.5 ± 12.7

24.6 ± 14.9

27.4 ± 16.8

  1. Note. The scores at ADAS-Cog reflect number of errors. Items are presented as Medians (quartiles 25, 75), sumscores are presented as Mean ± SD. n = 100 for ADAS-Cog items and n = 158 (56 men and 102 women) for ADAS-Cog sumscores. a The items Delayed word recall and Concentration are not included in the standard ADAS-Cog (max 70 points).