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Table 6 Synopsis of the degree of pathological changes and levels of various brain-derived proteins in the CSF

From: Brain-derived proteins in the CSF, do they correlate with brain pathology in CJD?

 

Spongiform change/neuronal loss/gliosis *

 

Cortical Regions

Subcortical Regions

Cerebellum

  

basal ganglia

thalamus

 

NSE

↔/↔/↔

↔/↑/↑

↑/↔/↔

↔/↑/↑

tau

↓/↓/↔

↔/↔/↑

↔/↓/↔

↑/↔/↑

phosphorylated tau

↓/↓/↓

↔/↔/↔

↑/↓/↓

↑/↔/↔

14-3-3

↓/↔/↔

↔/↔/↔

↑/↓/↔

↔/↔/↔

S 100b

↓/↓/↓

↔/↔/↑

↑/↓/↓

↔/↔/↑

PrP

↓/↓/↓

↔/↓/↓

↔/↔/↓

↑/↓/↔

Aβ 1–42

↓/↓**/↓

↓/↓/↓

↔/↓/↓

↑/↔/↔

  1. *: within the cells in the table the first arrow shows spongiform change, the second shows nerve cell loss and the third gliosis; only the strongest neuropathological changes among the different regions are shown in the table
  2. **: strong correlation
  3. ↔ correlation coefficient from -0.2 to +0.2: no correlation
  4. ↑ correlation coefficient from +0.2 to +0.6: weak correlation
  5. ↓ correlation coefficient from -0.2 to -0.6: weak correlation.