From: Brain-derived proteins in the CSF, do they correlate with brain pathology in CJD?
 | Spongiform change/neuronal loss/gliosis * | |||
---|---|---|---|---|
 | Cortical Regions | Subcortical Regions | Cerebellum | |
 |  | basal ganglia | thalamus |  |
NSE | ↔/↔/↔ | ↔/↑/↑ | ↑/↔/↔ | ↔/↑/↑ |
tau | ↓/↓/↔ | ↔/↔/↑ | ↔/↓/↔ | ↑/↔/↑ |
phosphorylated tau | ↓/↓/↓ | ↔/↔/↔ | ↑/↓/↓ | ↑/↔/↔ |
14-3-3 | ↓/↔/↔ | ↔/↔/↔ | ↑/↓/↔ | ↔/↔/↔ |
S 100b | ↓/↓/↓ | ↔/↔/↑ | ↑/↓/↓ | ↔/↔/↑ |
PrP | ↓/↓/↓ | ↔/↓/↓ | ↔/↔/↓ | ↑/↓/↔ |
Aβ 1–42 | ↓/↓**/↓ | ↓/↓/↓ | ↔/↓/↓ | ↑/↔/↔ |