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Table 5 Severity of lesion and concentrations of CSF markers (correlation coefficient): Gliosis

From: Brain-derived proteins in the CSF, do they correlate with brain pathology in CJD?

 

Cortical regions

Subcortical regions

Cerebellum

 

CG°

MFG°

ITG°

IPG°

AS°

Putamen

Caudate ncl.

MDT°

 

NSE

-0.0553

-0.0280

0.0104

-0.0345

-0.0445

0.298*

0.265*

0.0413

0.386*

Tau

-0.242

-0.174

-0.178

-0.160

-0.207

0.141

0.254

-0.0726

0.236

Tau phosphorylated

-0.423*

-0.175

-0.496*

-0.479*

-0.536*

-0.131

-0.111

-0.260

-0.090

14-3-3

-0.189

-0.155

-0.185

-0.0348

-0.114

0.0775

0.198

-0.132

-0.110

S 100b

-0.261

-0.188

-0.195

-0.271

-0.245

0.262

0.323*

-0.236

0.321

PrP

-0.344*

-0.260

-0.426*

-0.383*

-0.511*

-0.250

-0.168

-0.409*

-0.026

Aβ 1–42

-0.517*

-0.387*

-0.495*

-0.396*

-0.462*

-0.306

-0.357*

-0.387*

0.038

  1. ° MDT: medio-dorsal thalamus
  2. CG: cingulate gyrus
  3. MFG: medial frontal gyrus
  4. ITG: inferior temporal gyrus
  5. IPG: inferior parietal gyrus
  6. AS: area striata
  7. * significant, p ≤ 0.05.