Diseased muscles that lack dystrophin or laminin-α2 have altered compositions and proliferation of mononuclear cell populations

Table 1 Patterns of expression of Sca-1 and CD45 by mononucleate cells derived from healthy and diseased skeletal muscles.

		Percentage of cells with indicated expression pattern¹
Age	Genotype	Sca-1⁺/CD45^-	Sca-1⁺/CD45⁺	Sca-1^-/CD45⁺	Sca-1^-/CD45^-
3 weeks	C57BL/6	5.9 ± 3.5	1.0 ± 0.4	4.7 ± 1.7	88.0 ± 5.3
	Lama2 ^-/-	5.6 ± 1.8	3.3 ± 0.4	38.9 ± 15.9	52.2 ± 15.6
		P > 0.1	P < 0.03*	P < 0.01*	P < 0.01*
4 weeks	C57BL/10	12.0 ± 6.7	1.2 ± 0.2	8.3 ± 2.2	78.6 ± 4.3
	mdx	21.0 ± 7.4	6.4 ± 2.4	55.8 ± 11.3	16.7 ± 6.2
		P > 0.1	P = 0.09	P < 0.03*	P < 0.01*
7.5 weeks	C57BL/10	2.5 ± 0.6	0.2 ± 0.1	5.1 ± 0.2	92.0 ± 0.6
	mdx	1.8 ± 0.5	0.8 ± 0.3	28.9 ± 3.6	68.5 ± 4.1
		P > 0.1	P = 0.03*	P < 0.01*	P < 0.01*

¹Data are presented as ave. ± SD with n = 3 for all except 4 week old values where n = 2.
Unpaired, two-tailed t-tests (see Methods) were used to compare values from each pair of healthy and diseased muscles that were of the same age and expression pattern. P values are shown below the pair of tested values. P ≤ 0.05 was considered significant and indicated by an asterisk.

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