Figure 4

In most cell subsets, the percentage of cells that incorporated BrdU was lower in Lama2 ^-/- muscles, but higher in mdx muscles, than in healthy control muscles. A. In all cell subsets except Sca-1^-/CD45⁺, the percentage of cells that incorporated BrdU during 24 h in vivo was significantly increased in mdx cells compared to normal cells (see text for statistics). B. The percentage of cells that incorporated BrdU in Lama2 ^-/- muscles was significantly decreased compared to normal muscles in all subsets of Lama2 ^-/- cells with the exception of the rare double-positive Sca-1⁺/CD45⁺ subset in which incoporation was similar in diseased and healthy muscles (see text for statistics). Error bars represent standard deviation with n = 3. * indicates that the value for the mdx or Lama2 ^-/- muscles differed significantly from the corresponding control at P < 0.05.