A chronic fatigue syndrome – related proteome in human cerebrospinal fluid

BMC Neurology

Table 4 Multilinear regression (general linear model; GLM) analysis of the cohort 2 CFS – associated proteome. Proteins that were detected significantly more frequently in CFS than HC were shown in column 2. The significance (P), explained variance (R²), and probabilities for the association of each protein when stratified by CFS status, gender, and their cross-product were tabulated. The presence of at least 1 of the 5 CFS proteome proteins (right justified and bold italics) was sufficient to identify all the CFS subjects in Cohort 2 (B _1/5; see Results). (n.s., not significant).

	Cohort 2: Multilinear Analysis (GLM; individual samples)
GeneID	Cohort 2 CFS Proteome	P	R²	CFS	Gender	CFS × Gender
3868	*Keratin 16 (B* _1/5 )	0.0001	1	0.0001	0.0001	0.0001
2	*α2-Macroglobulin (B* _1/5 )	0.001	0.63	0.009	0.023	0.003
1356	Ceruloplasmin	0.001	0.63	0.009	0.023	0.003
5005	*Orosomucoid 2 (B* _1/5 )	0.001	0.63	0.009	0.023	0.003
5168	*Autotaxin (B* _1/5 )	0.001	0.63	0.009	0.023	0.003
351	APLP1	0.001	0.63	0.009	0.023	0.003
63827	BEHAB	0.001	0.63	0.009	0.023	0.003
140446	Keratin 6C	0.001	0.63	0.009	0.023	0.003
3872	Keratin 17	0.001	0.63	0.009	0.023	0.003
5004	Orosomucoid 1	0.001	0.63	0.009	0.023	0.003
3858	Keratin 10	0.013	0.48	n.s.	0.016	n.s.
721	C4B	0.022	0.44	0.007	n.s.	n.s.
5176	*PEDF (B* _1/5 )	0.022	0.44	0.007	n.s.	n.s.
2934	Gelsolin	0.033	0.41	n.s.	n.s.	0.011
84735	CNDP 1	0.037	0.40	n.s.	0.033	n.s.
3861	Keratin 14	0.037	0.40	n.s.	0.033	n.s.

ISSN: 1471-2377