Table 3 Chronic fatigue syndrome – associated cerebrospinal fluid proteomes. Proteins from the cohort 1 – and cohort 2 – related CFS proteomes (+) or not part of these proteomes (0) were shown in columns 2 and 3. The 5 proteins from cohort 2 that were most predictive of CFS (80% concordance) were defined by the "biosignature variable"B 1/5 (right justified and bold italics). The 2 cohorts were combined (n = 24 samples) and the frequencies of detection in all control (HC, n = 13) and CFS (n = 11) samples compared by ANOVA and Fisher's Exact Test. NCBI accession numbers (gi|) were given.
From: A chronic fatigue syndrome – related proteome in human cerebrospinal fluid
Cohort | CFS – Associated Proteome (all 24 samples) | HC % (n = 13) | CFS % (n = 11) | ANOVA | Fisher's Exact Test | ||
|---|---|---|---|---|---|---|---|
GeneID | |||||||
1 | 2 | ||||||
720, 721 | + | + | Complement C4A/B | 0% | 55% | 0.0010 | 0.0034 |
2934 | + | + | Gelsolin | 0% | 45% | 0.0046 | 0.011 |
3868 | 0 | + | Keratin 16 (B 1/5 ) | 0% | 45% | 0.0046 | 0.011 |
5176 | + | + | PEDF (B 1/5 ) | 0% | 45% | 0.0046 | 0.011 |
3537 | 0 | 0 | Ig λ | 15% | 64% | 0.014 | n.s. |
351 | + | + | APLP1 | 0% | 36% | 0.016 | 0.031 |
1356 | + | + | Ceruloplasmin | 0% | 36% | 0.016 | 0.031 |
2 | + | + | α-2-Macroglobulin (B 1/5 ) | 0% | 36% | 0.016 | 0.031 |
5005 | + | + | Orosomucoid 2 (B 1/5 ) | 0% | 36% | 0.016 | 0.031 |
5168 | + | + | Autotaxin | 0% | 36% | 0.016 | 0.031 |
1114 | 0 | 0 | Chromogranin B | 0% | 36% | 0.016 | 0.031 |
63827 | + | + | BEHAB (B 1/5 ) | 0% | 36% | 0.016 | 0.031 |
12 | + | 0 | α-1-Antichymotrypsin | 8% | 45% | 0.034 | n.s. |
3240 | + | 0 | Haptoglobin | 15% | 55% | 0.044 | n.s. |
3263 | 0 | 0 | Hemopexin | 15% | 55% | 0.044 | n.s. |
6696 | 0 | 0 | Secreted phosphoprotein 1 | 0% | 27% | 0.046 | n.s. |
3872 | 0 | + | Keratin 17 | 0% | 27% | 0.046 | n.s. |
140446 | 0 | + | Keratin 6C | 0% | 27% | 0.046 | n.s. |
718 | + | 0 | Complement C3 | 23% | 64% | 0.047 | n.s. |