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Table 4 Genotype and allele frequencies of the Apo-1/Fas Mva I polymorphism in thepresence and absence of the DRB1*1501

From: An examination of the Apo-1/Fas promoter Mva I polymorphism in Japanese patients with multiple sclerosis

 

DRB1*1501 positive

DRB1*1501 negative

 

MS patients N = 34 (%)

Controls N = 15 (%)

MS patients N = 73 (%)

Controls N = 88 (%)

Genotype frequency

    

G/G

13 (38.2%)

3 (20.0%)

15 (20.5%)

20 (22.7%)

G/A

14 (41.2%)

8 (53.3%)

47 (64.4%)

48 (54.5%)

A/A

7 (20.6%)

4 (26.7%)

11 (15.1%)

20 (22.7%)

Allele frequency

    

G

40 (58.8%)

14 (46.7%)

77 (52.7%)

88 (50.0%)

A

28 (41.2%)

16 (53.3%)

69 (47.3%)

88 (50.0%)

  1. The positive rates of HLA-DRB1*1501 in MS patients and controls were 34/107 (31.8%) and 15/103 (14.6%), respectively. The positive rate of DRB1*1501 in MS patients was significantly higher than that in controls (P < 0.005). There was no significant difference in the distributions of -670 polymorphisms in the Apo-1/Fas gene in DRB1*1501 positive or negative MS patients. (P > 0.05).
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BMC Neurology

ISSN: 1471-2377

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