Table 4 Univariate and multivariate logistic regression analyses of parameters associated with more severe ataxia group (SARA ≥ 15); (Tables show only significant parameters)
From: Clinical analysis of adult-onset spinocerebellar ataxias in Thailand
Univariate analysis | ||||
|---|---|---|---|---|
Variable | All 4 common SCAs | MJD, SCA1 and SCA2 | ||
| Â | Odd ratio (95% CI) | p-value | Odd ratio (95% CI) | p-value |
Age at onset (years) | 1.04 (0.99-1.08) | 0.075 | 1.04 (1.01-1.09) | 0.036 |
Age when assessment (years) | 1.08 (1.04-1.13) | <0.001 | 1.08 (1.04-1.14) | <0.001 |
Positive family history | 3.67 (1.12-11.97) | 0.031 | 5.13 (1.43-18.37) | 0.012 |
Ophthalmoparesis | 8.07 (2.80-23.10) | <0.001 | 7.25 (2.45-21.41) | <0.001 |
Sensory impairment | 6.40 (1.35-30.37) | 0.019 | 6.32 (1.32-30.31) | 0.021 |
Babinski’s sign | not significant |  | 2.67 (1.01-7.07) | 0.049 |
Multivariate logistic regression analysis: model 1 Consider age at onset as parameter | ||||
Variable | All 4 common SCAs | MJD, SCA1 and SCA2 | ||
| Â | Odd ratio (95% CI) | p -value | Odd ratio (95% CI) | p -value |
Ophthalmoparesis | 8.19 (2.74-24.44) | <0.001 | 7.56 (2.44-23.42) | <0.001 |
Sensory impairment | 6.64 (1.27-34.71) | 0.025 | 6.82 (1.29-36.01) | 0.024 |
Model 2 Consider age as parameter | ||||
Variable | All 4 common SCAs | MJD, SCA1 and SCA2 | ||
| Â | Odd ratio (95% CI) | p -value | Odd ratio (95% CI) | cx -value |
Age when assessed | 1.07 (1.02-1.13) | 0.004 | 1.08 (1.03-1.14) | 0.003 |
Ophthalmoparesis | 6.18 (1.90-20.03) | 0.002 | 5.62 (1.64-19.26) | 0.006 |
Sensory impairment | 9.28 (1.43-60.07) | 0.019 | 9.41 (1.40-63.34) | 0.021 |