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Table 3 Cox regression analysis of the association of the FGB −455 G/A genotype-by-smoking interaction term with longterm survival (all cause death endpoint) among patients with ischemic stroke of the SAM cohort (HRs and CIs are represented as crude)

From: Βeta-fibrinogen gene promoter A −455 allele associated with poor longterm survival among 55–71 years old Caucasian women in Finnish stroke cohort

FGB −455 G/A carrier and smoking status

All

Age group

Age group

Men

Women

Men

Women

HR 95% CI

55–71 years

72–85 years

(55–71 years)

(55–71 years)

(72–85 years)

(72–85 years)

HR 95% CI

HR 95% CI

HR 95% CI

HR 95% CI

HR 95% CI

HR 95% CI

All n

369

165

204

104

61

80

124

Event n

262

90

172

64

25

69

104

GG nonsmoker

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

GG smoker

1.03 (0.71-1.49)

1.35 (0.65-2.80)

0.91 (0.59-1.41)

1.07 (0.39-2.94)

3.46 (0.89-13.4)

1.38 (0.45-4.31)

0.83 (0.52-1.34)

GA/AA nonsmoker

1.34 (0.99-1.81)

2.00 (1.13-3.54)

1.27 (0.88-1.81)

1.21 (0.64-2.30)

5.21 (1.38-19.7)

1.62 (0.84-3.12)

1.17 (0.70-1.95)

GA/AA smoker

1.18 (0.83-1.67)

2.03 (1.11-3.70)

1.11 (0.70-1.75)

1.10 (0.56-2.17)

7.03 (1.81-27.3)

1.57 (0.74-3.30)

0.93 (0.47-1.84)

  1. Data shown for the total population and for, subgroups based on age (55–71 and 72–85 years old) and further divided by sex.