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Table 2 Clinical, diagnostic and treatment data of patients with anti-leucine rich glioma inactivated 1 protein encephalitis

From: Anti-leucine rich glioma inactivated 1 protein and anti-N-methyl-D-aspartate receptor encephalitis show distinct patterns of brain glucose metabolism in 18F-fluoro-2-deoxy-d-glucose positron emission tomography

Patient number

1

2

3

4

Psychiatric symptoms

-

+

-

-

Cognitive deficits

+ (working memory, attention, construction)

++

+

+

(memory)

(memory)

(memory)

Focal Seizures

+ (dystonic faciobrachial)

+

+

+ (dystonic faciobrachial)

Anti-LGI1 IgG titer in serum

1:100

1:100

1:100

1:100

Anti-LGI1 IgG titer in CSF

-

-

-

-

CSF leukocytes/μl

2

3

2

2

CSF oligoclonal bands

-

-

-

-

MRI lesions

unspecific

bitemporal T2-hyperintensities

-

-

Clinical onset to PET and treatment in months

6

1

12

2

mRS at time of PET

2

2

2

2

PET in narcosis

-

-

-

-

Evidence of Tumor

-

-

-

-

Intensive care treatment

-

-

-

-

Methylprednisolone

+

+

+

+

Plasmapheresis

+ (3 months interval)

+

+

-

Immunoglobulins

-

-

+

+

Immunosuppressive therapy

-

-

Cyclophospha-mide

-

mRS at follow up (months after PET)

1

0

3

0

 

(31)

(24)

(9)

(18)

  1. Abbreviations: Cerebrospinal fluid (CSF), positron emission tomography (PET), immunoglobulin G (IgG), leucine rich glioma inactivated 1 protein (LGI1), magnet resonance imaging (MRI), modified Rankin Scale (mRS).