Cystatin C, a novel indicator of renal function, reflects severity of cerebral microbleeds

BMC Neurology

Table 4 logistic regression analysis for the association of renal indicators and cerebral microbleeds

				Model 1^†			Model 2^‡
Variables	Unadjusted OR	95% CI	p	Adjusted OR	95% CI	p	Adjusted OR	95% CI	p	Adjusted OR		p
Log-Cystatin C, per SD^*	1.37	1.18-1.59	<0.01	1.30	1.05-1.69	0.02	1.27	1.04-1.61	0.02	1.73	1.82-3.08	<0.01
Log-albumin/Creatinine, per SD	0.90	0.81-1.01	0.08	0.90	0.82-1.03	0.93				1.00	0.87-1.14	0.96
Estimated GFR^*, per SD	1.01	0.64-0.91	<0.01	1.01	0.82-1.30	0.80	1.01	0.80-1.27	0.86

^*SD; standard deviation, GFR; glomerular filtration rate.
^†Model 1: Estimated GFR and log transformed cystatin C, and microalbumin/creatinine ratios were analyzed separately in an individual ordinal logistic model.
^‡Model 2: the first ordinal logistic regression analysis was performed using log transformed value of cystatin C and estimated GFR together. The second model used log transformed values of cystatin C and microalbumin/creatinine ratios as variables. All models were adjusted for covariates: age, sex, total cholesterol, diabetes, hypertension, dyslipidemia, previous heart disease, smoking, previous anti thrombotic or anticoagulant use, and white matter lesions.

ISSN: 1471-2377