Study population | Study period | Study | Sex- and age-specific counts | Diagnostic criteria | Other relevant information | Data obtained from author or external sources (yes/no) | F/M ratio (incident cases) | Criteria fulfilled for inclusion in incidence, by age and sex, trend, both or none | |
---|---|---|---|---|---|---|---|---|---|
First author and reference | Number of years and intervals | Number of cases (period) | Diagnostic delay (DD) in years | ||||||
Mean age at onset/diagnosis | |||||||||
1 | Faroe Islands | 1943-2007 | 81 | NO | <1986 Poser CD,CPr | Mean age at onset | NO | 1.25 | Trend |
Denmark | 65 | >1986 Poser, | 32y | ||||||
Joensen 2011 [19] | 7 | McDonald and Thompson | |||||||
2 | South-west Sardinia | 1958-2007 | YES | McDonald | - | NO | None | ||
Italy | 50 | ||||||||
Cocco 2011 [33] | 5 | ||||||||
3 | Iceland | 2002-2007 | 136 | YES | Poser CD for | Mean age at diagnosis 36.3y | YES | 3 | None |
Eliasdottir 2011 [46] | 6 | PPMS | Mean age at onset 32y | ||||||
1 | |||||||||
4 | Oppland | 1989-2001 | 148 | NO | Poser D and Pr, otherwise NS | - | NO | 2.02 | Trend |
Norway | 13 | ||||||||
Risberg 2011 [55] | 3 | ||||||||
5 | Faroe Islands | 1986-2007 | 43 | YES | Poser and/or McDonald, for PPMS | 36y at onset | NO | 1.53 | Age- and sex-specific incidence |
Denmark | 22 | ||||||||
Joensen 2010 [40] | 1 | ||||||||
6 | Ostrobothnia | 1992-2007 | 374 | NO | Poser CD | Mean age at onset 31.7y | NO | None | |
Finland | 16 | McDonald CD | Mean age at diagnosis 35.9y | ||||||
Krokki 2010 [24] | 1 | ||||||||
7 | Catania | 1975-2004 | 367 (75-04) | YES | Poser CD,Cpr,LSPr | Mean DD 1.4y | NO | 1.55 | Both |
Italy | 30 | 108 (00-04) | Age at onset increasing with time | ||||||
Nicoletti 2011 [10] | 6 | ||||||||
8 | Cardiff (Wales) | 1985-2007 | 582 | NO | Poser and McDonald | - | NO | 2.83 | None |
United Kingdom | 23 | (otherwise NS) | |||||||
Hirst 2009 [38] | 1 | ||||||||
9 | West Indies | 1992-2007 | 130 | YES | Revised McDonald | Mean age at onset 34.2y | YES | 4.2 | Both |
France | 15 | ||||||||
Cabre 2009 [8] | 3 | ||||||||
10 | San Marino | 1990-2005 | 33 | YES | Poser D,Pr | Mean DD decreasing with time (1.5 to 0.08y) | YES | 3.12 | Age- and sex-specific incidence |
Italy | 16 | ||||||||
Granieri 2008 [35] | 1 | ||||||||
11 | Greece 3 regions | 1984-2006 | 834 | NO | Poser and McDonald D | Mean DD 2.62y decreasing with time (3.23 to 1.79y) | NO | 1.38 | None |
Papathanasopoulos 2008 [60] | 23 | (otherwise NS) | Mean age at onset 31.41y | ||||||
4 | |||||||||
12 | Ferrara | 1965-2003 | 200 (90-03) | YES | Poser CD,CP | Mean DD decreasing with time (1.25 to 0.5y) | YES | 2.21 | Both |
Italy | 39 | 421 (65-03) | |||||||
Granieri 2007 [34] | 4 | ||||||||
13 | UK cohort | 1993-2000 | 642 | YES | Poser D,Pr, | - | NO | 2.24 | Age- and sex-specific incidence |
Alonso 2007 [48] | 8 | McDonald D,Pr | |||||||
1 | |||||||||
14 | Lorraine | 1990-2002 | 1658 | YES | Poser D,Pr | - | YES | 2.45 | Both |
France | 13 | ||||||||
Debouverie 2007 [31] | 1 | ||||||||
15 | Hordaland | 1953-2002 | 878 | NO | Poser | Mean DD decreasing with time (9.8-0.9y) | NO | 1.9 | Trend |
Norway | 50 | ||||||||
Grytten 2006 [51] | 10 | ||||||||
16 | Nordland | 1970-1999 | 259 (70-99) | YES | Poser | Mean DD 4.7y | YES | 1.87 | None |
Norway | 30 | 183 (85-99) | CDPr,,LSDPr | Mean age at diagnosis 39y | |||||
Alstadhaug 2005 [30] | 6 | ||||||||
17 | Catania | 1975-1999 | 155 (90-99) | YES | Poser CDPr,LSDPr | Mean at onset 33.3y | YES | 1.77 | Both |
Italy | 25 | Mean DD 1.7y | |||||||
Nicoletti 2005 [32] | 5 | ||||||||
18 | Sassari | 1965-1999 | 689 | NO | Poser | DD range 13.0-0.9y decreasing with time | NO | 2.57 | Trend |
Italy | 34 | Age at onset increasing with time | |||||||
Pugliatti 2005 [54] | 7 | ||||||||
19 | Monreale City | 1981-2000 | 19 | YES | Poser D,Pr | Mean DD 9.2y | NO | - | Trend |
Italy | 20 | ||||||||
Ragonese 2004 [41] | 2 | ||||||||
20 | Evros | 1974-1999 | 56 | NO | Poser CD,LSD | - | NO | 2.8 | Trend |
Greece | 26 | ||||||||
Piperidou 2003 [53] | 5 | ||||||||
21 | Vasterbotten County | 1988-1997 | 133 | YES | Poser | - | NO | 1.83 | Age- and sex-specific incidence |
Sweden | 10 | ||||||||
Sundström 2003 [37] | 1 | ||||||||
22 | Finland 3 districts | 1979-1993 | 1066 | NO | Poser CD or Lublin et al for PPMS | Mean age at diagnosis for districts (35.7,39.3,39.7y) | NO | 1.6 | None |
Sumelahti 2003 [59] | 15 | ||||||||
2 | |||||||||
23 | Lower (Bajo) Aragon | 1985-2002 | 42 | NO | Poser CD,CPr | DD 2y | NO | 1.93 | Trend |
Spain | 18 | Mean age at onset 29y | |||||||
Modrego 2003 [58] | 1 | ||||||||
24 | Padova | 1980-2000 | 580 | NO | Poser | Decreasing DD with time | NO | 1.92 | Trend |
Italy | 20 | 34y | |||||||
Ranzato 2003 [28] | 4 | ||||||||
25 | Iceland | 1951-1999 | 372 | NO | Poser | - | NO | 1.9 | Trend |
Benedikz 2002 [49] | 49 | ||||||||
10 | |||||||||
26 | Faroe Islands | 1943-1994 | 54 | NO | Poser CD,CPr | Individual age at onset available | NO | - | Trend |
Denmark | 52 | ||||||||
Kurtzke 2001 [21] | 8 | ||||||||
27 | Enna, Sicily | 1986-1995 | 16 | YES | Poser | Mean DD 3y | NO | 1.28 | None |
Italy | 10 | ||||||||
Grimaldi 2001 [39] | 1 | ||||||||
28 | Oslo | 1972-1996 | 794 | NO | Poser CD | For persons diagnosed 1986-1999 | NO | 2.38 | None |
Norway | 25 | DD 5.2y | |||||||
Celius 2001 [26] | 5 | Age at diagnosis 38.1y | |||||||
29 | Nuoro | 1955-1995 | 469 | YES | Poser (unspecified), Allison & Millar and Schumacher | Mean DD 4.61y | NO | 1.95 | Trend |
Italy | 41 | Mean age at onset 28.5y | |||||||
Granieri 2000 [27] | 8 | ||||||||
30 | Alcoi | 1986-1997 | 45 | NO | Poser CD,CPr | - | NO | 4 | Trend |
Spain | 12 | Mean age at onset 35.1y | |||||||
Mallada 2000 [57] | 1 | ||||||||
31 | Troms & Finnmark | 1974-1992 | 139 | NO | Rose DPrPs & | Mean DD 4.5y | NO | 1.36 | Trend |
Norway | 19 | Poser CD,CPr,LSD | Mean age at onset/diagnosis available | ||||||
Gronlie 2000 [50] | 4 | ||||||||
32 | Bagueria city | 1985-1994 | 20 | YES | Poser | Age at diagnosis 34.6y | NO | 1.86 | None |
Italy | 10 | Mean DD 2.6y | |||||||
Salemi 2000 [42] | 1 | ||||||||
33 | North-western Sardinia | 1962-1991 | 277 | YES | Poser CD,CPr,LSD,LSPr | DD range 8.0-1.8y decreasing with time | NO | 2.46 | Trend |
Italy | 30 | Mean age at onset 27y | |||||||
Rosati 1996 [56] | 6 | ||||||||
34 | Ferrara | 1965-1993 | 252 | YES | Poser CD,CPr | DD range 6.1-1.9y decreasing with time | NO | 2.07 | Trend |
Italy | 29 | Mean age at onset for specific forms | |||||||
Granieri 1996 [43] | 6 | ||||||||
35 | More & Romsdal | 1950-1991 | 330 | NO | McAlpine | DD potentially available 6y | NO | 1.41 | Trend |
Norway | 42 | 39.2y | |||||||
Midgard 1996 [52] | 8 | ||||||||
36 | Reggio Emilia & Modena | 1970-1990 | 316 (70-90) | YES | McAlpine CD,CPr | - | YES | 2.01 | Both |
Italy | 6 | 105 (85-90) | Mean age at onset 30.75y | ||||||
Guidetti 1995 [36] | 4 | ||||||||
37 | Modena | 1970-1990 | 183 (70-90) | YES | McAlpine D,Pr | - | YES | 1.9 | Both |
Italy | 6 | 59 (85-90) | Mean age at onset 30.8y | ||||||
Cavalletti 1994 [47] | 4 |