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Table 2 Epidemiological features of selected studies

From: Incidence of multiple sclerosis among European Economic Area populations, 1985-2009: the framework for monitoring

 

Study population

Study period

Study

Sex- and age-specific counts

Diagnostic criteria

Other relevant information

Data obtained from author or external sources (yes/no)

F/M ratio (incident cases)

Criteria fulfilled for inclusion in incidence, by age and sex, trend, both or none

 

First author and reference

Number of years and intervals

Number of cases (period)

  

Diagnostic delay (DD) in years

   
      

Mean age at onset/diagnosis

   

1

Faroe Islands

1943-2007

81

NO

<1986 Poser CD,CPr

Mean age at onset

NO

1.25

Trend

 

Denmark

65

  

>1986 Poser,

32y

   
 

Joensen 2011 [19]

7

  

McDonald and Thompson

    

2

South-west Sardinia

1958-2007

 

YES

McDonald

-

NO

 

None

 

Italy

50

       
 

Cocco 2011 [33]

5

       

3

Iceland

2002-2007

136

YES

Poser CD for

Mean age at diagnosis 36.3y

YES

3

None

Eliasdottir 2011 [46]

6

PPMS

Mean age at onset 32y

1

 

4

Oppland

1989-2001

148

NO

Poser D and Pr, otherwise NS

-

NO

2.02

Trend

Norway

13

Risberg 2011 [55]

3

5

Faroe Islands

1986-2007

43

YES

Poser and/or McDonald, for PPMS

36y at onset

NO

1.53

Age- and sex-specific incidence

Denmark

22

Joensen 2010 [40]

1

6

Ostrobothnia

1992-2007

374

NO

Poser CD

Mean age at onset 31.7y

NO

 

None

Finland

16

McDonald CD

Mean age at diagnosis 35.9y

Krokki 2010 [24]

1

7

Catania

1975-2004

367 (75-04)

YES

Poser CD,Cpr,LSPr

Mean DD 1.4y

NO

1.55

Both

Italy

30

108 (00-04)

Age at onset increasing with time

Nicoletti 2011 [10]

6

 

8

Cardiff (Wales)

1985-2007

582

NO

Poser and McDonald

-

NO

2.83

None

United Kingdom

23

(otherwise NS)

Hirst 2009 [38]

1

9

West Indies

1992-2007

130

YES

Revised McDonald

Mean age at onset 34.2y

YES

4.2

Both

France

15

Cabre 2009 [8]

3

10

San Marino

1990-2005

33

YES

Poser D,Pr

Mean DD decreasing with time (1.5 to 0.08y)

YES

3.12

Age- and sex-specific incidence

Italy

16

Granieri 2008 [35]

1

11

Greece 3 regions

1984-2006

834

NO

Poser and McDonald D

Mean DD 2.62y decreasing with time (3.23 to 1.79y)

NO

1.38

None

Papathanasopoulos 2008 [60]

23

(otherwise NS)

Mean age at onset 31.41y

4

12

Ferrara

1965-2003

200 (90-03)

YES

Poser CD,CP

Mean DD decreasing with time (1.25 to 0.5y)

YES

2.21

Both

Italy

39

421 (65-03)

Granieri 2007 [34]

4

13

UK cohort

1993-2000

642

YES

Poser D,Pr,

-

NO

2.24

Age- and sex-specific incidence

Alonso 2007 [48]

8

McDonald D,Pr

1

14

Lorraine

1990-2002

1658

YES

Poser D,Pr

-

YES

2.45

Both

France

13

Debouverie 2007 [31]

1

15

Hordaland

1953-2002

878

NO

Poser

Mean DD decreasing with time (9.8-0.9y)

NO

1.9

Trend

Norway

50

Grytten 2006 [51]

10

16

Nordland

1970-1999

259 (70-99)

YES

Poser

Mean DD 4.7y

YES

1.87

None

Norway

30

183 (85-99)

CDPr,,LSDPr

Mean age at diagnosis 39y

Alstadhaug 2005 [30]

6

17

Catania

1975-1999

155 (90-99)

YES

Poser CDPr,LSDPr

Mean at onset 33.3y

YES

1.77

Both

Italy

25

Mean DD 1.7y

Nicoletti 2005 [32]

5

18

Sassari

1965-1999

689

NO

Poser

DD range 13.0-0.9y decreasing with time

NO

2.57

Trend

Italy

34

Age at onset increasing with time

Pugliatti 2005 [54]

7

19

Monreale City

1981-2000

19

YES

Poser D,Pr

Mean DD 9.2y

NO

-

Trend

Italy

20

Ragonese 2004 [41]

2

20

Evros

1974-1999

56

NO

Poser CD,LSD

-

NO

2.8

Trend

Greece

26

Piperidou 2003 [53]

5

21

Vasterbotten County

1988-1997

133

YES

Poser

-

NO

1.83

Age- and sex-specific incidence

Sweden

10

Sundström 2003 [37]

1

22

Finland 3 districts

1979-1993

1066

NO

Poser CD or Lublin et al for PPMS

Mean age at diagnosis for districts (35.7,39.3,39.7y)

NO

1.6

None

Sumelahti 2003 [59]

15

2

23

Lower (Bajo) Aragon

1985-2002

42

NO

Poser CD,CPr

DD 2y

NO

1.93

Trend

Spain

18

Mean age at onset 29y

Modrego 2003 [58]

1

24

Padova

1980-2000

580

NO

Poser

Decreasing DD with time

NO

1.92

Trend

Italy

20

34y

Ranzato 2003 [28]

4

25

Iceland

1951-1999

372

NO

Poser

-

NO

1.9

Trend

Benedikz 2002 [49]

49

10

26

Faroe Islands

1943-1994

54

NO

Poser CD,CPr

Individual age at onset available

NO

-

Trend

Denmark

52

Kurtzke 2001 [21]

8

27

Enna, Sicily

1986-1995

16

YES

Poser

Mean DD 3y

NO

1.28

None

Italy

10

Grimaldi 2001 [39]

1

28

Oslo

1972-1996

794

NO

Poser CD

For persons diagnosed 1986-1999

NO

2.38

None

Norway

25

DD 5.2y

Celius 2001 [26]

5

Age at diagnosis 38.1y

29

Nuoro

1955-1995

469

YES

Poser (unspecified), Allison & Millar and Schumacher

Mean DD 4.61y

NO

1.95

Trend

Italy

41

Mean age at onset 28.5y

Granieri 2000 [27]

8

30

Alcoi

1986-1997

45

NO

Poser CD,CPr

-

NO

4

Trend

Spain

12

Mean age at onset 35.1y

Mallada 2000 [57]

1

31

Troms & Finnmark

1974-1992

139

NO

Rose DPrPs &

Mean DD 4.5y

NO

1.36

Trend

Norway

19

Poser CD,CPr,LSD

Mean age at onset/diagnosis available

Gronlie 2000 [50]

4

32

Bagueria city

1985-1994

20

YES

Poser

Age at diagnosis 34.6y

NO

1.86

None

Italy

10

Mean DD 2.6y

Salemi 2000 [42]

1

33

North-western Sardinia

1962-1991

277

YES

Poser CD,CPr,LSD,LSPr

DD range 8.0-1.8y decreasing with time

NO

2.46

Trend

Italy

30

Mean age at onset 27y

Rosati 1996 [56]

6

34

Ferrara

1965-1993

252

YES

Poser CD,CPr

DD range 6.1-1.9y decreasing with time

NO

2.07

Trend

Italy

29

Mean age at onset for specific forms

Granieri 1996 [43]

6

35

More & Romsdal

1950-1991

330

NO

McAlpine

DD potentially available 6y

NO

1.41

Trend

Norway

42

39.2y

Midgard 1996 [52]

8

36

Reggio Emilia & Modena

1970-1990

316 (70-90)

YES

McAlpine CD,CPr

-

YES

2.01

Both

Italy

6

105 (85-90)

Mean age at onset 30.75y

Guidetti 1995 [36]

4

37

Modena

1970-1990

183 (70-90)

YES

McAlpine D,Pr

-

YES

1.9

Both

 

Italy

6

59 (85-90)

  

Mean age at onset 30.8y

   
 

Cavalletti 1994 [47]

4