Figure 6
From: Detection of the GPI-anchorless prion protein fragment PrP226* in human brain
Correlation of D/N ratio in PrP226* assay with standard CJD classifications. The D/N ratio measured in V5B2/EM20-b DELFIA was compared (A) to the PrPSc type, (B) to the methionine (M)-valine (V) polymorphism at the codon 129, (C) to the presence or absence of the 14-3-3 protein found in CSF and (D) to PrPSc deposition type evaluated by immunohistochemistry with 6H4 after PK cleavage of 9 CJD/GSS samples of frontal cortex. The intensity of prion plaques, patchy/perivacuolar depositions and diffuse/synaptic depositions were evaluated at the scale 0 to 3. In all samples more than one deposition type was found. See also Additional file 2.