Groups | Time points | |||||
---|---|---|---|---|---|---|
Baseline n = 87 | 4 months n = 76 | 8 months n = 74 | 12 months* n = 69 | p-value1 | p-value2 | |
MMSE ± SD** | ||||||
Donepezil + stimulation therapy | 22.9 ± 4.5 | 22.9 ± 4.5 | 22.9 ± 4.9 | 22.5 ± 5.5 | 0.443 | 0.449 |
Placebo + standard care | 23.3 ± 4.9 | 23.8 ± 4.2 | 23.6 ± 4.6 | 24.1 ± 4.7 | ||
Clock Drawing Test ± SD** | ||||||
Donepezil + stimulation therapy | 2.9 ± 1.1 | 2.9 ± 1.1 | 2.8 ± 1.2 | 3.1 ± 1.0 | 0.064 | 0.035 |
Placebo + standard care | 2.9 ± 1.2 | 3.2 ± 1.0 | 3.3 ± 1.0 | 3.3 ± 1.1 | ||
ADAS-cog ± SD** | ||||||
Donepezil + stimulation therapy | 19.3 ± 8.7 | 19.2 ± 8.2 | 17.2 ± 9.5 | 16.1 ± 8.7 | 0.554 | 0.458 |
Placebo + standard care | 17.2 ± 8.0 | 16.3 ± 7.1 | 16.3 ± 8.5 | 15.1 ± 7.9 |