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Table 1 Clinical data of the whole cohort as well as clinical and molecular-genetic subtypes

From: Retinal nerve fibre layer loss in hereditary spastic paraplegias is restricted to complex phenotypes

  Age [years] Disease duration [years] SPRS [scoring points] Phenotype
HSP-a (n=28) 48.1 (8–75) 19.1 (440) 20.8 (330) complex & pure, see subgroups
HSP-p (n=22) 49.5 (8–75) 21.8 (5–43) 21.5 (3–31) spastic paraparesis, pure phenotype
HSP-c (n=6) 42.8 (22–60) 9.5 (4–18) 18 (8–31) most frequent complicating symptoms: gaze-evoked-nystagmus or ataxia
SPG4 (n=13) 46.1 (8–74) 21.5 (7–37) 20.8 (3–30) spastic paraparesis, pure phenotype
SPG5 (n=1) 48 43 23 pure phenotype
SPG7 (n=3) 38.3 (28–48) 9.7 (4–14) 17.7 (8–31) one pure, two complex phenotypes (see text)
  1. Data are given as mean values and range in brackets for all HSP-patients (HSP-a) and for clinically pure phenotypes (HSP-p), complex phenotypes (HSP-c) as well as molecular-genetic (SPG4, SPG5, SPG7) subgroups.