From: Risk of fractures in patients with multiple sclerosis: record-linkage study
Fracture (ICD code†) | Observed | Expected | Rate Ratio (95% confidence interval) | Exact P value |
---|---|---|---|---|
All fractures‡ | 4414 | 2238.3 | 1.99 (1.93-2.05) | <0.001* |
Ribs (S22.2-S22.4 ) | 161 | 130 | 1.24 (1.06-1.45) | 0.007 |
Clavicle (S42.0) | 83 | 52.6 | 1.59 (1.26-1.97) | <0.001* |
Humerus (S42.2-S42.4, S42.7) | 415 | 204.2 | 2.05 (1.86-2.26) | <0.001* |
Forearm (S52) | 448 | 493.5 | 0.91 (0.82-1.00) | 0.042 |
Wrist/Hand (S62) | 157 | 188.1 | 0.83 (0.71-0.98) | 0.025 |
Pelvis/Lumbar spine (S32.0-S32.8) | 293 | 187.7 | 1.57 (1.39-1.76) | <0.001* |
Tibia/Ankle (S82) | 1393 | 506.1 | 2.81 (2.66-2.96) | <0.001* |
Foot (S92) | 194 | 95.5 | 2.05 (1.77-2.37) | <0.001* |
Femur - neck of (S72.0-S72.2) | 1579 | 574.2 | 2.79 (2.65-2.93) | <0.001* |
Femur - other (S72.3-S72.8) | 543 | 85.8 | 6.69 (6.12-7.29) | <0.001* |
Femur - unspecified (S72.9) | 88 | 18.5 | 4.91 (3.92-6.08) | <0.001* |
Fractures up to 1 year after first MS admission | Observed | Expected | Rate Ratio (95% confidence interval) | Exact P value |
All fractures‡ | 717 | 373.4 | 1.94 (1.80-2.08) | <0.001* |
Ribs (S22.2-S22.4) | 22 | 20.2 | 1.09 (0.68-1.65) | 0.779 |
Clavicle (S42.0) | 11 | 7.7 | 1.43 (0.71-2.57) | 0.319 |
Humerus (S42.2-S42.4, S42.7) | 76 | 28.3 | 2.72 (2.14-3.41) | <0.001* |
Forearm (S52) | 73 | 69.9 | 1.05 (0.82-1.32) | 0.752 |
Wrist/Hand (S62) | 22 | 28.2 | 0.78 (0.49-1.18) | 0.278 |
Pelvis/Lumbar spine (S32.0-S32.8) | 51 | 26.5 | 1.94 (1.44-2.56) | <0.001* |
Tibia/Ankle (S82) | 200 | 80.5 | 2.53 (2.19-2.91) | <0.001* |
Foot (S92) | 17 | 15.5 | 1.10 (0.64-1.77) | 0.793 |
Femur - neck of (S72.0-S72.2) | 293 | 88.2 | 3.39 (3.01-3.81) | <0.001* |
Femur - other (S72.3-S72.8) | 58 | 12.3 | 4.88 (3.68-6.35) | <0.001* |
Femur - unspecified (S72.9) | 18 | 2.7 | 6.91 (4.04-11.09) | <0.001* |
Fractures excluding those occurring in the first year after first MS admission | Observed | Expected | Rate Ratio (95% confidence interval) | Exact P value |
All fractures‡ | 3697 | 1864.9 | 2.00 (1.93-2.07) | <0.001* |
Ribs (S22.2-S22.4) | 139 | 109.7 | 1.27 (1.07-1.50) | 0.006 |
Clavicle (S42.0) | 72 | 44.8 | 1.61 (1.26-2.04) | <0.001* |
Humerus (S42.2-S42.4, S42.7) | 339 | 175.8 | 1.95 (1.74-2.17) | <0.001* |
Forearm (S52) | 375 | 423.6 | 0.88 (0.80-0.98) | 0.019 |
Wrist/Hand (S62) | 135 | 159.9 | 0.84 (0.71-1.00) | 0.053 |
Pelvis/Lumbar spine (S32.0-S32.8) | 242 | 161.1 | 1.51 (1.32-1.71) | <0.001* |
Tibia/Ankle (S82) | 1193 | 425.6 | 2.86 (2.70-3.03) | <0.001* |
Foot (S92) | 177 | 80.1 | 2.24 (1.92-2.60) | <0.001* |
Femur - neck of (S72.0-S72.2) | 1286 | 486 | 2.68 (2.54-2.84) | <0.001* |
Femur - other (S72.3-S72.8) | 485 | 73.5 | 7.00 (6.37-7.67) | <0.001* |
Femur - unspecified (S72.9) | 70 | 15.8 | 4.57 (3.55-5.81) | <0.001* |