Table 2 Associations of polymorphisms involved in dopaminergic neurotransmission and Parkinson's disease
Polymorphism | Cases (%) (n = 238) | Controls (%) (n = 369) | P | Adjusted* OR (95% CI) |
|---|---|---|---|---|
COMT rs4680 | Â | Â | Â | |
   GG (ancestral) | 98 (41.2) | 179 (48.5) |  | 1.0 |
   GA | 116 (48.7) | 166 (45.0) |  | 1.26 (0.88 - 1.79) |
   AA | 24 (10.1) | 24 (6.5) | 0.106 | 1.86 (0.98 - 3.50) |
| Â | Â | PHWE = 0.077 | Â | Ptrend = 0.044 |
   GA + AA vs. GG | 140 (58.8) | 190 (51.4) |  | 1.33 (0.95 - 1.87) |
MAOB rs1799836 | Â | Â | Â | |
   AA (A) (ancestral) | 192 (80.7) | 273 (74.0) |  | 1.0 |
   AG | 34 (14.3) | 68 (18.4) |  | 0.61 (0.37 - 0.99) |
   GG (G) | 12 (5.0) | 28 (7.6) |  | 0.55 (0.26 - 1.16) |
| Â | Â | PHWE < 0.0001 | 0.154 | Ptrend = 0.016 |
AA (A) vs. AG + GG (G) | Â | Â | Â | 1.70 (1.12 - 2.58) |
Female | Â | Â | Â | Â |
   AA (ancestral) | 110 (74.8) | 156 (68.1) |  | 1.0 |
   AG | 34 (23.1) | 68 (29.7) |  | 0.60 (0.36 - 0.99) |
   GG | 3 (2.13) | 5 (2.18) |  | 0.90 (0.21 - 3.97) |
| Â | Â | PHWE = 0.443 | 0.368 | Ptrend = 0.084 |
Male | Â | Â | Â | Â |
   A | 82 (90.1) | 117 (83.7) |  | 1.0 |
   G | 9 (9.89) | 23 (16.3) | 0.166 | 0.45 (0.19 - 1.09) |
DRD2 rs1800497 | Â | Â | Â | |
   TT (ancestral) | 29 (12.2) | 52 (14.1) |  | 1.0 |
   TC | 117 (49.2) | 192 (52.0) |  | 1.04 (0.61 - 1.77) |
   CC | 92 (38.7) | 125 (33.9) | 0.460 | 1.32 (0.77 - 2.28) |
| Â | Â | PHWE = 0.111 | Â | Ptrend = 0.204 |
   CC vs. TC + TT |  |  |  | 1.28 (0.90 - 1.82) |
DRD4 rs1800955** | Â | Â | Â | |
   TT (ancestral) | 81 (34.0) | 136 (37.0) |  | 1.0 |
   TC | 122 (51.3) | 162 (44.0) |  | 1.23 (0.85 - 1.79) |
   CC | 35 (14.7) | 70 (19.0) | 0.173 | 0.88 (0.54 - 1.47) |
| Â | Â | PHWE = 0.083 | Â | Ptrend = 0.928 |
   TT + TC vs. CC |  |  |  | 1.27 (0.80-2.00) |