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Table 2 Interval likelihood ratios for tau and S100B

From: Diagnostic accuracy of cerebrospinal fluid protein markers for sporadic Creutzfeldt-Jakob disease in Canada: a 6-year prospective study

Marker

Intervala

N (sCJD)b

N (non-CJD)b

iLRc

95% CI

Tau

0-500

5

591

0.06

0.03-0.14

 

500-1,000

10

138

0.50

0.27-0.92

 

1,000-3,000

24

65

2.5

1.7-3.9

 

3,000-10,000

40

27

10.2

6.5-16.0

 

10,000-∞

41

5

56.4

22.8-140.0

S100B

0-2.0

8

581

0.09

0.05-0.18

 

2.0-3.0

19

147

0.85

0.55-1.3

 

3.0-4.0

26

43

4.0

2.5-6.2

 

4.0-∞

69

31

14.6

10.0-21.4

  1. a Interval values are in pg/mL for tau, and in ng/mL for S100B.
  2. b Numbers of patients with test results falling into each interval are shown.
  3. c iLR - interval likelihood ratio. Values are estimates of iLR for CSF tau and S100B at illustrative cutoff thresholds.