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Figure 4 | BMC Neurology

Figure 4

From: Diagnostic accuracy of cerebrospinal fluid protein markers for sporadic Creutzfeldt-Jakob disease in Canada: a 6-year prospective study

Figure 4

Post-test probabilities for diagnosis of sCJD. Point estimates (closed circles for a positive test result; vertical bars for a negative test result) and 95% credible intervals (horizontal bars) of post-test probabilities for a diagnosis of sCJD are plotted for various CSF markers and cutoff thresholds. For each estimate, Bayes' theorem was applied to CSF marker assay results, and 95% credible intervals were estimated by modeling on a beta distribution using the software Post_Test_Probabilities. Pre-test probability of sCJD (based on sCJD prevalence in the overall study population) and 95% confidence interval are indicated by the open circle and the horizontal bar. Cutoff thresholds used are listed on the left.

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