Table 3 Predictors of cognitive impairment at Year 3, defined as impaired performance on ≥3 cognitive tests (multivariate logistic regression)
Odds ratio | 95% CI | |
|---|---|---|
Stable/increased T2 lesion volume over 3 years | ||
Treatment with sc IFN β-1a 44 µg tiw | 0.45 | 0.23-0.91 |
Baseline BH lesion volume | 1.01 | 1.00-1.01 |
Number of new T2 lesions | 1.13 | 1.02-1.26 |
Stable/increased BH volume over 3 years | ||
Treatment with sc IFN β-1a 44 µg tiw | 0.46 | 0.23-0.92 |
ESS score at baseline | 0.82 | 0.69-0.98 |
Presence of new BH over 3 years | 3.21 | 1.52-6.75 |
Three or more impaired cognitive tests at Year 3 | ||
Baseline T2 lesion volume | 1.01 | 1.00-1.01 |
Verbal IQ* | 0.92 | 0.87-0.98 |
IFN β-1a, 44 μg sc tiw | 0.31 | 0.10-0.98 |