Table 3 Pharmacotherapy Treatment Persistence Patterns
Persistence Measure | DMD-treated patients (n = 4,462) |
|---|---|
Persistence on DMD therapy | Mean ± SD |
Days from index diagnosis to 1st DMD | 158 ± 274 |
Days of continuous therapy for index DMDs (no gaps > 30 days) | 511 ± 476 |
Days of continuous therapy for all DMDs (no gaps > 30 days) | 565 ± 503 |
Days, first to last for index DMD (with gaps)* | 683 ± 525 |
Days, first to last for all DMDs (with gaps)* | 798 ± 540 |
Gap analysis for the index DMD | % of patients |
No gaps in index therapy > 30 days | 71.0% |
Gaps in index therapy of 31-60 days | 20.6% |
Gaps in index therapy > 60 days (restarts) | 16.5% |
Gaps of 61-90 days | 8.4% |
Gaps of 91-120 days | 4.4% |
Gaps > 120 days | 8.3% |
Mean days to restart (Mean ± SD) | 159 ± 151 |
Switched from index DMD | 21.3% |
Mean days to switch (Mean ± SD) | 445 ± 386 |
Discontinued all DMDs before end of follow-up† | 27.7% |
Mean days to discontinuation (Mean ± SD) | 527 ± 437 |