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Table 3 MS Concordance rates in Monozygotic Twins of HLA DRB1*1501-positive (ZH+) and HLA DRB1*1501-negative (ZH-) Probands *.

From: The genetic basis of multiple sclerosis: a model for MS susceptibility

 

Monozygotic Twins of MS Probands

 
 

HLA DRB1*1501 Positive

HLA DRB1*1501 Negative

Totals

Concordant for MS (C)

9

11

20

Discordant for MS (D)

31

42

73

Totals

40

53

93

Pair-wise Concordance †

ZH+ = (9/40) = 23%

ZH- = (11/53) = 21%

 

Proband-wise Concordance ††

ZH+ = 31%

ZH- = 29%

 

Proband-wise Concordance (Adjusted) †††

ZH+ = 17%

ZH- = 16%

 
  1. * Data derived from: Willer et al., 2003 [11]
  2. † Pair-wise rates calculated as (Z = C/(C + D).
  3. †† Proband-wise concordance rates calculated as (Z = 2C/(2C + D) adjusted [21] for the overall probability of doubly ascertaining concordant twin-pairs (54%) in the Willer, et al., 2003 [11] study.
  4. ††† See Text, Equation (20)
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BMC Neurology

ISSN: 1471-2377

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