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Table 15 (11) The estimated Number of Loci (n) in for Genotypes including or not including HLA DRB1*1501.

From: The genetic basis of multiple sclerosis: a model for MS susceptibility

 

Estimated Number of Susceptibility Genes Required (n) for all Loci

 

11

12

13

14

15

16

17

Frequency of Susceptibility (r)

Estimated (n) the for Genotypes including HLA DRB1*1501

r = 0.25

3

3

3

3

3

3

3

r = 0.33

3 - 10

3 - 11

11 - 11

3 - 13

11 - 14

14 - 15

15

r = 0.5

10 - 11

11 - 12

12 - 13

13 - 14

14 - 15

15 - 16

17

r = 1

11

12

13

14

15

16

17

r = 2

11

12

13

14

15

16

17

r = 4

11

12

13

14

15

16

17

r = 8

11

12

13

14

15

16

17

r = 16

11

12

13

14

15

16

17

Frequency of Susceptibility (r)

Estimated (n) the for Genotypes not including HLA DRB1*1501

r = 0.25

12

13

14 - 15

15 - 16

16 - 17

18

19

r = 0.33

11 - 12

12 - 13

14

15

15 - 16

16 - 17

18

r = 0.5

11

12

13

14

15

16

17

r = 1

11

12

13

14

15

16

17

14 - 15r = 2

11

12

13

14

15

16

17

r = 4

11

12

13

14

15

16

17

r = 8

11

12

13

14

15

16

17

r = 16

11

12

13

14

15

16

17

  1. (Bold and underlined as designated for "Closeness of Fit" calculations in Table 8)
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BMC Neurology

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